Detalhe da pesquisa
1.
Synthesis and biological evaluation of nusbiarylin derivatives as bacterial rRNA synthesis inhibitor with potent antimicrobial activity against MRSA and VRSA.
Bioorg Chem
; 124: 105863, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35580381
2.
Nusbiarylins Inhibit Transcription and Target Virulence Factors in Bacterial Pathogen Staphylococcus aureus.
Int J Mol Sci
; 21(16)2020 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32796751
3.
Nusbiarylins, a new class of antimicrobial agents: Rational design of bacterial transcription inhibitors targeting the interaction between the NusB and NusE proteins.
Bioorg Chem
; 92: 103203, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31446238
4.
Novel anticancer oridonin derivatives possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: Design, synthesis, biological evaluation and nitric oxide release studies.
Bioorg Med Chem Lett
; 26(12): 2795-2800, 2016 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27158140
5.
Discovery of Novel Polycyclic Heterocyclic Derivatives from Evodiamine for the Potential Treatment of Triple-Negative Breast Cancer.
J Med Chem
; 64(23): 17346-17365, 2021 12 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34844412
6.
HPLC, quantitative NMR and HRMS spectroscopic data of nusbiarylins as a new class of antimicrobial agents.
Data Brief
; 29: 105313, 2020 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-32154348
7.
Simple Method for Studying in Vitro Protein-Protein Interactions Based on Protein Complementation and Its Application in Drug Screening Targeting Bacterial Transcription.
ACS Infect Dis
; 5(4): 521-527, 2019 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30834747
8.
Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
Eur J Med Chem
; 178: 214-231, 2019 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31185412
9.
Design, synthesis, and biological evaluation of NAD(P)H: Quinone oxidoreductase (NQO1)-targeted oridonin prodrugs possessing indolequinone moiety for hypoxia-selective activation.
Eur J Med Chem
; 132: 310-321, 2017 May 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28395199
10.
A Novel Potent Anticancer Compound Optimized from a Natural Oridonin Scaffold Induces Apoptosis and Cell Cycle Arrest through the Mitochondrial Pathway.
J Med Chem
; 60(4): 1449-1468, 2017 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28165738